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pentobarbital decreases levels of toremifene by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. CYP3A4 inducers enhance rate of toremifene metabolism, lowering the steady-state concentration in serum.pentobarbital will decrease the extent or effect of zolpidem by affecting hepatic/intestinal enzyme CYP3A4 metabolis